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K87pAcF had the highest affinity (13.7 nM), a 3.7-fold increase compared to the wild type (Fig

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For example, T cells and B cells in GALT can recognize and eliminate translocated bacteria while simultaneously producing anti-inflammatory cytokines such as IL-10 to sustain intestinal immune tolerance (134, 135).Moreover, innate immune cells recognize pathogen-associated molecular patterns via pattern recognition receptors (e.g., Toll-like receptors) and activate signaling pathways like NF-B, thereby modulating the intensity and duration of the immune response (136)

doi: 10.1212/01.wnl.0000247740.47667.03